Prenatal Dexamethasone Exposure Induced Ovarian Developmental Toxicity and Transgenerational Effect in Rat Offspring
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چکیده
منابع مشابه
Prenatal Mercuric Chloride Exposure Causes Developmental Deficits in Rat Cortex
Introduction: Environmental pollution with heavy metals such as mercury is a major health problem. Growing studies on the field have shown the deleterious effects of mercury on human and nonhuman nervous system, especially in infants, however the effects of prenatal exposure to mercuricchloride on cortical development are not yet well understood. The aim of this study was to investigate the eff...
متن کاملPrenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring.
In this study, it has been clearly demonstrated that prenatal dexamethasone treatment (Dex; 0.05 mg/kg on gestational days 17, 18, and 19) resulted in the significant reductions of 5-hydroxytryptamine (5-HT) turnover in four brain regions, including the neocortex, hippocampus, hypothalamus, and midbrain + pons-medulla (M+P-M) but not in the striatum in the offspring at 3 and 14 wk of life, as w...
متن کاملThe Effect of Prenatal Exposure to Restraint Stress on Hippocampal Granule Neurons of Adult Rat Offspring
Objective(s) It is well known that prenatal stresses (PS) induce a variety of neurobiological and behavioral alterations, some of them involving the hippocampal formation. This study aimed to determine whether restraint stress influences the neuronal volume and number of granule cells in the hippocampus of adult rat offspring. Materials and Methods Ten Wistar pregnant rats were randomly divi...
متن کاملDevelopmental effects of prenatal cocaine exposure on 5-HT1A receptors in male and female rat offspring.
Prenatal cocaine exposure results in behavioral abnormalities throughout development in rats, but little is known regarding the biological mechanisms underlying these abnormalities. Pregnant rats received subcutaneous twice-daily injections (1 ml/kg) of normal saline or 15 mg/kg of cocaine hydrochloride throughout gestation (gestation days 1-20). Following delivery, pups were placed with untrea...
متن کاملprenatal mercuric chloride exposure causes developmental deficits in rat cortex
introduction: environmental pollution with heavy metals such as mercury is a major health problem. growing studies on the field have shown the deleterious effects of mercury on human and nonhuman nervous system, especially in infants, however the effects of prenatal exposure to mercuricchloride on cortical development are not yet well understood. the aim of this study was to investigate the eff...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2018
ISSN: 1945-7170
DOI: 10.1210/en.2018-00044